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目的:探讨阿托伐他汀钙(立普妥)对脑梗死患者颈动脉斑块的影响及机制。方法:对60例有颈动脉斑块的脑梗塞患者在常规抗血小板聚集治疗的基础上加用立普妥10mg/d,持续6个月作为治疗组,以60例有颈动脉斑块的脑梗塞仅常规抗血小板聚集组为对照组。观察双侧颈动脉斑块积分和治疗前后的血清C-反应蛋白水平(CRP)。结果:治疗组双侧颈动脉斑块积分显著小于对照组(P<0.05),治疗组6个月后CRP水平明显下降。结论:立普妥可显著稳定动脉粥样硬化斑块,促进斑块消退,有利于抑制炎症反应。
Objective: To investigate the effect and mechanism of atorvastatin calcium (Lipitor) on carotid artery plaque in patients with cerebral infarction. Methods: Sixty cerebral infarction patients with carotid artery plaque were treated with Lipitor (10 mg / d) for 6 months as the treatment group on the basis of routine antiplatelet aggregation. Sixty patients with carotid artery plaque Infarct only routine anti-platelet aggregation group as control group. Bilateral carotid plaque score and serum C-reactive protein level (CRP) before and after treatment were observed. Results: The score of bilateral carotid artery plaque in treatment group was significantly lower than that in control group (P <0.05). CRP level in treatment group decreased significantly after 6 months. Conclusion: Lipitor can significantly stabilize the atherosclerotic plaque and promote the regression of plaque, which is beneficial to suppress the inflammatory reaction.