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目的探讨西地那非治疗肺动脉高压患者的应临床疗效及安全性。方法选取广东省湛江市第二中医医院2015年1-6月收治的特发性肺动脉高压或先天性心脏病肺动脉高压患者26例作为研究对象,给予口服西地那非,治疗前后测定患者的肺动脉收缩压、6 min步行距离、心脏指数、Borg呼吸困难指数、心输出量等,同时检测视力及相关生化指标,记录服药期间的不良反应发生情况。结果治疗后患者肺动脉高压功能分级、心功能分级、Borg评级均较治疗前降低,差异均有统计学意义(均P<0.05);6 min步行距离较治疗前增加,差异有统计学意义(P<0.05)。结论西地那非能改善肺动脉高压患者的心功能和呼吸困难情况,显著提高其运动能力,同时肺动脉压也有不同程度的降低,不良反应少,是可供选择的安全有效药物之一。
Objective To investigate the clinical efficacy and safety of sildenafil in patients with pulmonary hypertension. Methods Twenty-six patients with idiopathic pulmonary hypertension or congenital heart disease with pulmonary hypertension admitted from Jan.-Jun. 2015 in Zhanjiang Second Hospital of Traditional Chinese Medicine, Guangdong Province, were enrolled in this study. Patients were given oral sildenafil before and after treatment for pulmonary artery Systolic blood pressure, walking distance 6 minutes, cardiac index, Borg index of dyspnea, cardiac output and so on. At the same time, the visual acuity and related biochemical indexes were measured and the adverse reactions during the medication were recorded. Results After treatment, the pulmonary hypertension classification, heart function classification and Borg rating were significantly lower than those before treatment (all P <0.05). The walking distance at 6 min was significantly higher than that before treatment (P <0.05). Conclusion Sildenafil can improve cardiac function and dyspnea in patients with pulmonary hypertension, significantly improve their ability to exercise, while pulmonary arterial pressure is also reduced to varying degrees, with fewer adverse reactions, is one of the safe and effective choice of drugs.