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目的：探讨2型糖尿病家系非糖尿病一级亲属在糖耐量正常时胰岛素第一时相分泌情况。方法：收集江苏省常州市2型糖尿病家系中非糖尿病一级亲属(NGT组)42例、家系2型糖尿病(T2DM组)49例、并以无糖尿病家族史的46例健康成人为对照(NC组),进行25g静脉葡萄糖耐量试验(IVGTT)测定空腹及IVGTT后1、2、4、6、10min的血胰岛素水平。结果：2型糖尿病家系非糖尿病一级亲属0、1、4、6、10min胰岛素和健康成人对照组之间有统计学差异(P＜0．05)。结论：2型糖尿病家系中糖耐量正常的一级亲属胰岛素的第一时相分泌和没有道传背景的健康成人已存在显著差异。
Objective: To investigate the first-phase insulin secretion in non-diabetic first-degree relatives of type 2 diabetic families with normal glucose tolerance. Methods: Forty-two non-diabetic first-degree relatives (NGT group) and 49 family type 2 diabetes mellitus (T2DM) were collected from type 2 diabetic families in Changzhou, Jiangsu Province. Forty-six healthy adults without a family history of diabetes mellitus (NC) Group), 25g intravenous glucose tolerance test (IVGTT) was used to measure fasting insulin levels at 1, 2, 4, 6 and 10 min after IVGTT. Results: There was a significant difference (P <0.05) between 0,1,4,6 and 10min insulin of non-diabetic first-degree relatives of type 2 diabetic families and healthy adults. CONCLUSIONS: There was a significant difference in first phase secretion of insulin of first-degree relatives with impaired glucose tolerance in type 2 diabetic families and in healthy adults without background on Taoism.