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目的 寻找新鲜羊膜重建眼表术后主要并发症的有效治疗措施。方法 对 32例 32只严重化学伤患眼施新鲜羊膜重建眼表手术 ,按随机方法将研究对象分为投药组及对照组各 16只眼 ;治疗组于术后 1周应用 0 .5mg/ml的FK 5 0 6滴眼液 ,对照组应用 1%CsA滴眼液 ,观察两组病例术后睑球粘连角膜新生血管、假性胬肉及移植组织排斥反应指数。结果 在随访期内 ,投药组的组织排斥反应时间、发生率、角膜假性胬肉及睑球粘连、四个指标均明显优于对照组。结论 局部应用FK 5 0 6可有效提高新鲜羊膜重建眼表手术的成功率。
Objective To find the effective treatment for the major complications of reconstructive ocular surface surgery by amniotic membrane. Methods 32 cases of severe chemical injury eyes were implanted amniotic membrane amniotic membrane reconstruction surgery, the randomized study will be divided into the treatment group and the control group of 16 eyes; the treatment group at 1 week after the application of 0.5 mg / ml Of FK506 eye drops, the control group with 1% CsA eye drops, observe the two groups of patients with corneal neovascularization corneal neovascularization, false pterygium and transplantation rejection response index. Results During the follow-up period, the rejection rate, incidence, corneal pseudo-pterygium and symblepharon in the administration group were significantly better than those in the control group. Conclusion Local application of FK506 can effectively improve the success rate of fresh amniotic membrane reconstruction of ocular surface surgery.