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目的:通过研究特发性肺纤维化患者肺泡灌洗液中IL-6、TNF-a的含量变化及对IPF诊断的意义。方法:我院近五年经HRCT诊断IFP为实验组(n=40),正常患者为对照组(n=40),经电子气管镜生理盐水15ml行肺泡灌洗,回收肺泡灌洗液,测定及比较两组肺泡灌洗液中IL-6、TNF-a的含量变化。结果:电子支气管镜肺泡灌洗液中IL-8、TNF-a均高于正常人(<0.0001,<0.0001),表明ILD患者肺泡灌洗液中IL-8、TNF-a明显高于正常患者。结论:IPF组肺泡灌洗液中IL-6、TNF-a较正常组明显升高,可以推论IL-6、TNF-a参与了IPF的进程,对IPF的诊断及治疗有一定的价值。
OBJECTIVE: To study the changes of IL-6 and TNF-a in bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis and its significance in the diagnosis of idiopathic pulmonary fibrosis. Methods: IFP was diagnosed by HRCT in the past five years in our hospital (n = 40), normal control group (n = 40), bronchoalveolar lavage fluid The levels of IL-6 and TNF-a in the bronchoalveolar lavage fluid of the two groups were compared. Results: The levels of IL-8 and TNF-a in bronchoalveolar lavage fluid were higher than those in normal people (<0.0001, <0.0001), indicating that IL-8 and TNF-a in bronchoalveolar lavage fluid of patients with ILD were significantly higher than those of normal patients . CONCLUSION: IL-6 and TNF-a in BALF in IPF group are significantly higher than those in normal group. It can be inferred that IL-6 and TNF-a are involved in the process of IPF, which is of value to the diagnosis and treatment of IPF.