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白血病细胞多药耐药 (ＭＤＲ)是目前白血病治疗中的一大难题。ＧＳＴ是一种与ＭＤＲ相关的酶 ,它能催化亲电物质与其结合 ,并可与亲脂性细胞毒药物结合增强其水溶性 ,促进药物排泄而降低抗癌药物的作用 ,与耐药有一定关系〔1〕。我们应用免疫组化Ｓ Ｐ法测定 6 0例ＡＮＬＬ患者
Leukemia multidrug resistance (MDR) is currently a major problem in the treatment of leukemia. GST is an MDR-related enzyme that catalyzes the binding of electrophilic substances to it and binds to lipophilic cytotoxic drugs to enhance its water solubility, promote drug excretion and reduce the effect of anti-cancer drugs, which is related to drug resistance 〔1〕. We used immunohistochemical SP method determination of 60 patients with ANLL