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目的通过检测子痫前期及子痫患者全血中CD62p和GPⅡb/Ⅲa表达水平,以探讨血小板活化状态。方法采用流式细胞术于剖宫产术前(入院后24h内)和术后48h内,检测子痫前期及子痫、正常孕晚期、正常未孕妇女全血中CD62p和GPⅡb/Ⅲa水平。结果分娩前轻度子痫前期组CD62p与正常未孕组、正常孕晚期组相比较,无显著性差异(P>0.05);分娩前重度子痫前期及子痫组CD62p明显高于正常未孕组、正常孕晚期组、轻度子痫前期组,有显著性差异(P<0.01);分娩后各组之间均无统计学差异(P>0.05);重度子痫前期及子痫组分娩后CD62p较分娩前明显降低,有显著性差异(P<0.01)。分娩前轻度子痫前期组GPⅡb/Ⅲa水平与正常未孕组、正常孕晚期组相比较,无显著性差异(P>0.05);分娩前重度子痫前期及子痫组GPⅡb/Ⅲa水平明显高于正常未孕组、正常孕晚期组、轻度子痫前期组(P<0.01);分娩后各组之间均无显著性差异(P>0.05);重度子痫前期及子痫组分娩后GPⅡb/Ⅲa水平明显降低与分娩前相比较,有显著性差异(P<0.01)。结论联合检测重度子痫前期及子痫患者CD62p和GPⅡb/Ⅲa水平,不但可以指导临床治疗及预防,并对该病的病因学研究提供了新理念。
Objective To detect the expression of CD62p and GPⅡb / Ⅲa in whole blood of preeclampsia and eclampsia to explore the platelet activation status. Methods The levels of CD62p and GPⅡb / Ⅲa in preeclampsia and eclampsia, normal pregnant women and normal pregnant women were measured by flow cytometry before cesarean section (within 24h after admission) and within 48 hours after operation. Results Before delivery, there was no significant difference in CD62p between mild preeclampsia group and normal nonpregnant group and normal late pregnancy group (P> 0.05). CD62p in preeclampsia and preeclampsia group was significantly higher than that in normal nonpregnant (P <0.01). There was no significant difference between the two groups after delivery (P> 0.05). The incidence of severe preeclampsia and eclampsia CD62p was significantly lower than before delivery, there was a significant difference (P <0.01). The levels of GPⅡb / Ⅲa in mild preeclampsia group before delivery were not significantly different from those in normal nonpregnant group and normal pregnant women (P> 0.05). The levels of GPⅡb / Ⅲa in preeclampsia and preeclampsia group were significantly higher (P <0.01). There was no significant difference among all groups after delivery (P> 0.05). The incidence of severe preeclampsia and eclampsia group was significantly higher than that of normal preeclampsia group, normal pregnancy group and mild preeclampsia group After the level of GP Ⅱ b / Ⅲ a was significantly lower than that before delivery, there was a significant difference (P <0.01). Conclusions The combined detection of CD62p and GPⅡb / Ⅲa levels in patients with severe preeclampsia and eclampsia not only can guide clinical treatment and prevention, but also provides new ideas for the etiology of the disease.