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转录因子GATA3被证实在尿路上皮癌(UC)中高表达,然而GATA3与UC相关性标志物CD7及p63的表达关系尚未见系统性报道,亦未见GATA3在区域性转移灶中表达的敏感性评估。本组将69例膀胱肿瘤的原发灶及转移灶相配对制作成高密度组织芯片,包含48例单纯乳头状、9例平坦型UC,9例具有腺样、小细胞、鳞状、巨细胞及浆样特征的混合性癌,以及3例腺癌。免疫表型:GATA3在UC原发灶[62/69(90%)]及淋巴结转移灶[64/69(93%)]中表达,在转移灶中的表达强度明显高于原发灶(P=0.03)。原发灶
The transcription factor GATA3 was confirmed to be highly expressed in urothelial carcinoma (UC). However, the relationship between GATA3 and the expression of CD7 and p63, a marker of UC, has not been systematically reported and the sensitivity of GATA3 expression in regional metastases has not been reported Evaluation. The group of 69 cases of primary tumor and metastasis of bladder cancer matched to make high-density tissue microarray, including 48 cases of simple papillary, 9 cases of flat UC, 9 cases with adenoid, small cells, squamous, giant cells And mixed features of the plasma-like cancer, and 3 cases of adenocarcinoma. Immunophenotype: GATA3 was expressed in primary tumor [62/69 (90%)] and lymph node metastasis [64/69 (93%)], and its expression intensity in metastasis was significantly higher than that in primary tumor = 0.03). Primary tumor