论文部分内容阅读
目的通过检测研究,分析血清卵泡抑素(FS)在子宫内膜异位症(EMT)中的表达和意义,探讨其在卵巢型EMT诊疗中的价值。方法以该院2013年1月~2014年10月收治的75例卵巢型EMT患者为研究对象,其中卵巢EMT组45例,卵巢外EMT组30例,并选取同期卵巢良性肿瘤患者45例为卵巢良性组,正常健康妇女75例为健康组。分别使用酶联免疫吸附测定(ELISA)和电化学发光实验(ECISA)测定4组对象的血清FS与CA125水平,比较两者对EMT诊断的敏感度和特异性。结果卵巢EMT组血清FS水平(1 328.13±312.43)ng/L显著高于卵巢良性组(301.54±56.32)ng/L和健康组(74.56±45.72)ng/L,差异均有统计学意义(P<0.05)。卵巢EMT组血清CA125水平与卵巢良性组和健康组比较,差异均有统计学意义(P<0.001),但其与卵巢外EMT组相比,差异无统计学意义(P=0.282)。结论在EMT诊断中,血清FS较血清CA125敏感度高,其对EMT特别是卵巢型EMT的诊断价值较高。
Objective To investigate the expression and significance of serum follistatin (FS) in endometriosis (EMT) and to explore its value in the diagnosis and treatment of ovarian EMT. Methods Seventy-five patients with ovarian-type EMT admitted to our hospital from January 2013 to October 2014 were enrolled in this study. Among them, 45 were ovarian EMT and 30 were ovarian EMT. Forty-five ovarian benign tumors were selected as ovarian 75 cases of benign group and normal healthy women were healthy group. The serum levels of FS and CA125 in four groups were measured by enzyme-linked immunosorbent assay (ELISA) and electrochemical luminescence assay (ECISA) respectively. The sensitivity and specificity of the two assays for EMT were compared. Results The level of serum FS in ovarian EMT group was significantly higher than that in benign ovarian group (301.54 ± 56.32) ng / L and healthy group (74.56 ± 45.72) ng / L, with statistical significance (P <0.05). The serum level of CA125 in ovarian EMT group was significantly higher than that in benign ovarian group and healthy group (P <0.001), but there was no significant difference between ovarian EMT group and EMT group (P = 0.282). Conclusions In the diagnosis of EMT, serum FS is more sensitive than serum CA125, and it is more valuable for the diagnosis of EMT, especially ovarian EMT.