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目的比较不同治疗方案治疗耐多药结核病的临床效果。方法选取焦煤集团中央医院自2011年5月至2013年5月收治的80例耐多药结核病患者,随机分为观察组(司帕沙星组)与参考组(氧氟沙星组)各40例,比较两组患者的临床治疗效果,不良反应发生率,治疗后3、6个月痰菌转阴率。结果观察组患者临床治疗效果明显优于参考组(P<0.05),患者不良反应发生率明显低于参考组(P<0.05),治疗3、6个月观察组患者痰转阴率明显高于参考组(P<0.05),差异有统计学意义。结论司帕沙星治疗耐多药结核病临床效果更好,安全性高,值得推广使用。
Objective To compare the clinical effects of different treatment regimens in the treatment of multidrug-resistant tuberculosis. Methods Eighty patients with multidrug-resistant tuberculosis who were treated in Central Hospital of Coking Coal from May 2011 to May 2013 were randomly divided into observation group (sparfloxacin group) and reference group (ofloxacin group) Cases, the clinical efficacy of two groups were compared, the incidence of adverse reactions, 3,6 months after treatment sputum negative conversion rate. Results The clinical efficacy of the observation group was significantly better than that of the reference group (P <0.05), and the incidence of adverse reactions in the observation group was significantly lower than that of the reference group (P <0.05). The sputum negative conversion rate of the observation group was significantly higher than that of the reference group Reference group (P <0.05), the difference was statistically significant. Conclusion Sparfloxacin treatment of MDR-TB clinical effect is better, high safety, it is worth promoting the use of.