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目的探讨抗β1和α1肾上腺素受体(β1受体和α1受体)自身抗体是否与高血压病合并肾损害有关。方法以合成的β1和α1受体多肽片段为抗原,应用酶联免疫吸附测定(ELISA)技术,检测61例高血压并肾损害患者,60例高血压无肾损患者及40例正常人,血清中抗G-蛋白偶联型β1和α1受体自身抗体。结果高血压病并肾损害组抗β1和α1受体抗体阳性率为62.3%(38/61)和50.8%(31/61),明显高于高血压无肾损害组的13.3%(7/60)和10.0%(6/60)及正常对照组12.5%(5/40)和7.5%(3/40),比较差异有统计学意义(P<0.001)。结论血清抗G-蛋白偶联型β1和α1受体自身抗体可能与高血压合并肾损害发病有关。
Objective To investigate whether autoantibodies against β1 and α1 adrenergic receptors (β1 and α1 receptors) are associated with hypertension and renal damage. Methods The synthetic β1 and α1 receptor peptide fragments were used as antigen. Enzyme linked immunosorbent assay (ELISA) was used to detect 61 patients with hypertension and renal damage, 60 patients with hypertension without renal damage and 40 normal persons. Serum Medium anti-G-protein coupled β1 and α1 receptor autoantibodies. Results The positive rates of anti-β1 and α1 receptor antibodies in patients with hypertension and renal damage were 62.3% (38/61) and 50.8% (31/61), respectively, which were significantly higher than those in patients without renal damage (13.3%, 7/60 ), 10.0% (6/60) and normal control group (12.5% (5/40)) and 7.5% (3/40) respectively. The difference was statistically significant (P <0.001). Conclusion Serum anti-G-protein-coupled β1 and α1 receptor autoantibodies may be associated with the pathogenesis of hypertension and renal damage.