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目的 :探讨人冠状动脉内膜、中膜平滑肌细胞核 (smoothmusclecellnuclei,SMCN)体密度的年龄性变化。方法 :应用常规石蜡切片 ,Verhoeff氏铁苏木精 -VanGieson染色 ,对 33例 15岁～ 5 0岁正常男性左冠状动脉前室间支(以下简称冠状动脉 )内膜、中膜SMCN体密度进行了图像定量分析。结果 :正常男性冠状动脉SMCN体密度的年龄性变化不明显 ,但 31岁以后的同年龄段内膜、中膜不同部位间SMCN体密度有显著性差异 ,其中内膜高于中膜 ,31～岁 (P <0 .0 5 ) ,41～ 5 0岁 (P <0 .0 1)。结论 :正常男性冠状动脉壁平滑肌细胞的增殖能力与年龄无明显关系 ;31岁以后的同年龄段内膜中平滑肌细胞的增殖能力强于中膜。
Objective: To investigate the age-related changes in body density of smooth muscle cell nuclei (SMCN) in human coronary arteries. Methods: 33 cases of 15-year-old 50-year-old normal left anterior interventricular branch of coronary artery (hereinafter referred to as coronary artery) intima and media SMCN body density was performed using conventional paraffin sections, Verhoeff’s iron hematoxylin -VanGieson staining Image quantitative analysis. Results: There was no significant difference in the body density of SMCN between normal men and women. However, there were significant differences in the density of SMCN between the different parts of the same age group after 31 years of age, Years old (P <0.05), 41 ~ 50 years old (P <0.01). CONCLUSION: The proliferative capacity of normal human coronary artery smooth muscle cells has no significant relationship with age. The proliferation of smooth muscle cells in the same age group after 31 years old is stronger than that in the media.