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目的分析比较国产与进口短效曲普瑞林在体外受精长方案中的降调效果和临床结局。方法对357例应用长方案行IVF/ICSI的不孕患者进行回顾性分析,按应用降调药物的不同分为2组,A组应用国产曲普瑞林,B组应用进口短效曲普瑞林达必佳,观察两组患者的降调效果、降调费用及临床结局。结果 A组HCG日LH水平高于短效达必佳组(P<0.05),但达到降调效果;A组降调节药物产生的费用明显低于B组(P<0.05)。两组患者取卵数、优胚数、移植数、冷冻数、卵裂率、妊娠率及着床率差异无统计学意义(P>0.05)。结论国产曲普瑞林可以在节省降调节费用的同时达到与进口达必佳相同的降调效果和临床结局。
Objective To compare and analyze the down-regulation effect and clinical outcome of domestic and imported short-acting triptorelin in in vitro fertilization long program. Methods A retrospective analysis of 357 infertile patients who underwent IVF / ICSI with long-term program was divided into two groups according to the application of the drug for down-regulation. A was treated with domestic triptorelin, while B was treated with imported short-acting triptorelin Linda will be good, observe the two groups of patients with the effect of lowering the cost and clinical outcomes. Results The LH level of HCG in group A was higher than that in short-acting DBP group (P <0.05), but the effect was down-regulated. The cost of lowering drug in group A was significantly lower than that in group B (P <0.05). There were no significant differences in the numbers of retrieved oocytes, excellent embryos, transplanted numbers, frozen numbers, cleavage rate, pregnancy rate and implantation rate between the two groups (P> 0.05). Conclusion Domestic triptorelin can achieve the same effect and clinical outcome of dabigatran as imported dabigatran while saving the adjustment cost.