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目的探讨Livin、Caspase-9在食管鳞癌(ESCC)发生发展中的作用。方法采用免疫组化法检测65例食管鳞癌组织及癌周正常食管组织(对照组)中的表达,分析其与食管鳞癌临床病理特征的关系。结果食管鳞癌组织中Livin阳性表达率显著高于对照组(P<0.05);其表达与组织学分型、淋巴结转移和临床分期有明显关系(P<0.05)。Caspase-9在食管鳞癌组织中的阳性表达率显著低于对照组(P<0.05);其表达与淋巴结转移和临床分期有明显关系(P<0.05);二者在食管鳞癌组织中的表达呈负相关(P<0.05)。结论 Livin、Caspase-9在食管鳞癌的发生发展过程中起着重要的作用。
Objective To investigate the role of Livin and Caspase-9 in the development of esophageal squamous cell carcinoma (ESCC). Methods The expressions of 65 esophageal squamous cell carcinomas and normal esophageal cancer tissues (control group) were detected by immunohistochemistry, and their relationship with the clinicopathological characteristics of esophageal squamous cell carcinoma was analyzed. Results The positive expression rate of Livin in esophageal squamous cell carcinoma was significantly higher than that in the control group (P <0.05). The expression of Livin in esophageal squamous cell carcinoma was significantly correlated with the histological type, lymph node metastasis and clinical stage (P <0.05). The positive expression rate of Caspase-9 in esophageal squamous cell carcinoma tissue was significantly lower than that in the control group (P <0.05), and the expression of Caspase-9 was significantly correlated with lymph node metastasis and clinical stage (P <0.05) The expression was negatively correlated (P <0.05). Conclusion Livin and Caspase-9 play an important role in the development of esophageal squamous cell carcinoma.