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多巴胺(Dppamine)是继肾上腺素和去甲肾上腺素之后第三种内源性儿茶酚胺。在体内,它也是去甲肾上腺素的前体。一、药理作用:多巴胺的药理作用比较复杂。在中枢,黑质—绞状体通路存在多巴胺能神经元,其功能低下与震颤麻痹(帕金森氏征)的发病机制有关。由于多巴胺不易通过血脑屏障,可以应用能通过血脑屏障的左旋多巴,它在中枢脱羧后变为多巴胺,可补充中枢多巴胺能神经元功能不足,以治疗震颤麻痹。吩噻
Dopamine is the third endogenous catecholamine following epinephrine and norepinephrine. It is also a precursor of norepinephrine in the body. First, the pharmacological effects: The pharmacological effects of dopamine more complicated. In the central nervous system, dopaminergic neurons exist in the substantia nigra and the strait pathway, and their dysfunction is associated with the pathogenesis of parkinsonism (Parkinson’s). Because dopamine does not easily cross the blood-brain barrier, levodopa, which crosses the blood-brain barrier, becomes dopamine after central decarboxylation and complements the dysfunction of central dopaminergic neurons to treat paralysis. Phenothiazine