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目的探讨高压氧治疗对新生儿缺氧缺血性脑病(HIE)患儿神经元特异性烯醇化酶(NSE)的影响,为今后HIE患儿的临床治疗提供参考。方法 80例HIE患儿,按照入院先后顺序分为对照组与观察组,各40例。对照组给予常规治疗,观察组在常规治疗的基础上给予高压氧治疗,对比两组患儿治疗前后NSE水平的变化情况。结果治疗前,两组患儿的NSE水平间比较无明显差异,治疗7 d后观察组的NSE平均水平为(7.36±3.49)μg/L,对照组NSE平均水平为(9.87±3.54)μg/L,观察组明显低于对照组,差异具有统计学意义(P<0.05)。结论在常规治疗的基础上开展高压氧治疗能够明显降低HIE患儿的NSE水平,减轻临床症状与对脑细胞的损伤,值得在临床中推广应用。
Objective To investigate the effect of hyperbaric oxygen therapy on neuron-specific enolase (NSE) in neonates with hypoxic-ischemic encephalopathy (HIE) and provide a reference for future clinical treatment of HIE. Methods Eighty HIE infants were divided into control group and observation group according to the order of hospital admission, 40 cases in each group. The control group was given conventional therapy. The observation group was given hyperbaric oxygen therapy on the basis of routine treatment. The changes of NSE level in both groups before and after treatment were compared. Results Before treatment, there was no significant difference in NSE levels between the two groups. The average level of NSE in the observation group was (7.36 ± 3.49) μg / L after treatment for 7 days, and that in the control group was (9.87 ± 3.54) μg / L, the observation group was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Hyperbaric oxygen therapy based on routine treatment can significantly reduce the NSE level in children with HIE and reduce clinical symptoms and damage to brain cells, which is worth popularizing in clinic.