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便秘型肠易激综合征(C-IBS)是一种临床最常见的功能性肠道疾病,临床主要表现为腹部不适、腹痛、大便排出困难或排便间隔时间延长,伴有抑郁、焦虑等精神症状,未发现胃肠道结构改变以及生化学检查的异常,经完善相关检查可排除相关器质性疾病。C-IBS当归属于中国医学“腹痛”“便秘”的范畴。C-IBS发病的病理生理机制,目前尚未完全阐明,目前认为其发病与胃肠运动功能紊乱、微生物群的改变、内脏高敏感性、基因遗传因素、炎症及免疫成分的改变、Cajal间质细胞和脑-肠轴的神经内分泌功能紊乱等有关。研究其发病机制对于提高患者的生活质量及合理利用医疗资源至关重要。现从中西医两方面对其发病机制的最新进展作一综述。
Constipation-predominant irritable bowel syndrome (C-IBS) is one of the most common functional bowel diseases in clinic. The main clinical manifestations include abdominal discomfort, abdominal pain, difficulty in excretion of stool, prolonged interval of defecation, depression and anxiety Symptoms, no changes in the structure of the gastrointestinal tract and abnormalities in biochemical tests were found, and related organic diseases could be ruled out by improving the relevant tests. C-IBS Angelica belongs to the category of Chinese medicine “abdominal pain ” “constipation ”. The pathophysiological mechanism of C-IBS is not fully elucidated at present. It is thought that the pathogenesis of C-IBS is related to gastrointestinal motility disorders, changes in microbiota, visceral hypersensitivity, genetic genetic factors, changes in inflammation and immune components, Cajal stromal cells And brain - intestinal axis of neuroendocrine dysfunction and so on. Studying its pathogenesis is essential to improve the quality of life of patients and to make rational use of medical resources. Now from the two aspects of Chinese and Western medicine on its pathogenesis of the latest developments are reviewed.