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目的 探讨抑癌基因PTEN的蛋白表达与上皮性卵巢癌的发生、发展之间的关系。方法 对 74例上皮性卵巢癌应用免疫组化方法检测PTEN蛋白的表达。结果 上皮性卵巢癌中PTEN蛋白有一定的表达缺失 ,在G1、G2 级组织表达率 (90 6 2 %)高于G3级组织表达率 (6 6 6 7%) ,二者差异有显著性 ;不同的临床分期中 ,Ⅰ、Ⅱ期阳性表达为 2 2 / 2 4 (91 6 7%) ,Ⅲ、Ⅳ期阳性表达为 3 5 / 5 0 (70 %) ,二者差异有显著性。在浆液性和粘液性两种不同的组织类型间 ,表达率分别为 82 98%和 6 6 6 7%,二者无明显差别。结论 PTEN蛋白的表达缺失在上皮性卵巢癌的发生、发展过程中有一定的作用 ,且与病变进展和分化有关
Objective To investigate the relationship between the expression of tumor suppressor gene PTEN and the occurrence and development of epithelial ovarian cancer. Methods 74 cases of epithelial ovarian cancer were detected by immunohistochemistry PTEN protein expression. Results The expression of PTEN protein was underexpressed in epithelial ovarian cancer. The expression of PTEN protein in G1 and G2 was higher than that in G3 (666.7%) (90 6 2%). The difference was significant. Among the different clinical stages, the positive expression in stage Ⅰ and stage Ⅱ was 2 2/2 4 (91 6 7%), the positive expression in stage Ⅲ and stage Ⅳ was 35/50 (70%), the difference was significant. In serous and mucinous tissue types, the expression rates were 82 98% and 66 6%, respectively, with no significant difference between the two. Conclusions The loss of PTEN protein may play an important role in the development and progression of epithelial ovarian cancer and is related to the progression and differentiation of the disease