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目的 :探讨长期居住海拔 50 0 0m以上地区人群睡眠呼吸障碍的特征以及红景天复方和乙酰唑胺的调节作用 ;方法 :对居住海拔 5380m高原一年的 2 4名青年随机分为A组 (红景天组 )、B组 (乙酰唑胺组 )和C组 (红景天 +乙酰唑胺组 ) ,每组 8人 ,在服药前和服药 2 4天后分别进行睡眠结构和睡眠呼吸监测 ;结果 :服药 2 4天后非快动眼睡眠(NREM)Ⅰ、Ⅱ期缩短 ,Ⅲ、Ⅳ期及快动眼睡眠 (REM)期延长 ,均有非常显著性差异 (P <0 .0 1 ) ;服药后每小时周期性呼吸 (PB)和呼吸暂停 (SA)的次数及平均时间减少 ,均有显著性意义 (P <0 .0 5或P <0 .0 1 ) ;结论 :红景天复方和乙酰唑胺均能明显改善高原睡眠结构和睡眠呼吸紊乱 ,抑制中枢性睡眠呼吸暂停 (CSA) ,但两种药物合用并无明显的协同作用。
Objective: To investigate the characteristics of sleep-disordered breathing in long-term residents above 50 000 m altitude and the regulatory effect of Rhodiola and acetazolamide.Methods: Twenty-four youths who lived in 5380 m altitude for one year were randomly divided into group A Rhodiola group), group B (acetazolamide group) and group C (Rhodiola + acetazolamide group), with 8 in each group. Sleep structure and sleep respiration were monitored before and 24 days after treatment. Results: There was a significant difference (P <0.01) in NREM Ⅰ, Ⅱ shortening, Ⅲ, Ⅳ and REM sleep duration after 24 days of medication. (P <0.05 or P <0.01) .It was found that the combination of Rhodiola rosea And acetazolamide can significantly improve the plateau sleep structure and sleep-disordered breathing and inhibit central sleep apnea (CSA), but there is no obvious synergistic effect between the two drugs.