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目的:观察太白米不同提取部位对血栓形成及血小板聚集的影响。方法:采用皮下注射0.1%盐酸肾上腺素复合冰水浴造成大鼠血瘀模型,按Chandler体外法形成大鼠体外血栓,测定太百米不同组分对血栓长度、湿重的影响;应用Born氏比浊法测定太百米不同组分在体外胶原诱导血小板聚集功能的影响。结果:太白米正丁醇、水提取部位血栓长度和湿重都显著减少;太白米正丁醇提取物不同剂量对家兔体外血小板聚集都有抑制作用。在0.33μl时,与对照组比较,1分钟聚集率、斜率有抑制和降低作用,3分钟聚集率、5分钟聚集率、最大聚集率有抑制作用,在1μl时,斜率有明显降低作用。结论:太白米正丁醇、水提取部位血栓形成及血小板聚集有一定抑制作用。
Objective: To observe the effect of different extraction parts of white rice on thrombosis and platelet aggregation. Methods: The model of blood stasis was induced by subcutaneous injection of epinephrine hydrochloride and epinephrine combined with ice-water bath in rats. The in vitro thrombus of rat was formed by Chandler’s in vitro method. The influence of different components of 100-meter-long on thrombus length and wet weight was measured. Determination of turbidity method to determine the effect of different components of Baigemei on collagen - induced platelet aggregation in. Results: The n-butanol and water extract of thompson were significantly reduced in thrombus length and wet weight. However, the n-butanol extract at different doses had inhibitory effects on platelet aggregation in vitro. When the concentration was 0.33μl, the aggregation rate and the slope were inhibited and decreased by 1 minute, the aggregation rate at 3 minutes, the aggregation rate at 5 minutes, and the maximum aggregation rate were inhibited. When the concentration was 1μl, the slope was significantly reduced. CONCLUSION: Butanol, water extract thrombosis and platelet aggregation have a certain inhibitory effect.