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本文以培养人胚软骨细胞技术,对两种抗氧化剂—硒和微生素 E 在腐殖酸损伤软骨细胞过程中的生物效应,分别做了观察。结果表明:1、富里酸50ppm 作用四天,对培养软骨细胞具有显著的损伤效应;2、提前二天加硒0.1ppm,则富里酸损伤软骨细胞效应不发生;3、但维生素 E2.5ppm,对上述保护作用并不明显。微量元素硒和维生素 E 的这种差别显然是它们的生物效应,特别是抗氧化作用机理不同所致,本文对此做了讨论。作者还对腐殖酸、硒和大骨节病的病因发病学的可能关系,提出了自己的见解。
In this paper, the culture of human embryonic chondrocytes, the biological effects of two antioxidants - selenium and vitamin E in humic acid-damaged chondrocytes were observed respectively. The results showed that: 1, fulvic acid 50ppm for four days, on cultured chondrocytes have a significant damage effect; 2, two days ahead of selenium 0.1ppm, then the acid-rich chondrocyte injury does not occur; 3, but vitamin E2.5ppm, The above protection is not obvious. This difference between trace elements selenium and vitamin E is clearly their biological effects, especially due to different antioxidant mechanisms, this article discussed. The authors also put forward their own views on the possible relationship between the pathogenesis of humic acid, selenium and Kashin-Beck disease.