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本文以辣根过氧化物酶(HRP)与福氏完全佐剂混合成的乳液对雄性豚鼠作一次免疫,追踪腘淋巴结中抗体形成细胞的分化途径和变化。一次免疫后抗体形成细胞分化的途径与前文所述的二次免疫是相同的,只是免疫应答开始时间较二次免疫晚。在免疫后8天的皮质区和髓质区,同时出现分散的含抗体的阳性细胞,主要是浅棕色的小淋巴细胞和中淋巴细胞。从10天起,这二个区域的阳性细胞明显增加,细胞染色加深,至24天,阳性细胞大量增多达高峰,以棕色和栋褐色的前浆细胞和浆细胞为主,淋巴结的大部分区域充满着阳性细胞。从30天起,阳性细胞在皮质和髓质区都急副下降,至50天,淋巴结中只存在少数分散的阳性细胞,部分细胞成为不规则形的残留浆细胞。
In this study, male guinea pigs were immunized with an emulsion mixed with horseradish peroxidase (HRP) and Freund’s complete adjuvant to track the differentiation pathways and changes of antibody-forming cells in popliteal lymph nodes. The pathway for antibody-forming cell differentiation after one immunization is the same as the second immunization described above except that the immune response starts later than the second immunization. At 8 days post-immunization, cortical and medullary areas were disseminated with antibodies containing positive cells, mainly light brown lymphocytes and small lymphocytes. From 10 days onwards, the positive cells in these two regions increased significantly and the cells stained darker. By 24 days, a large number of positive cells reached the peak, mainly brown and brown frontal plasma cells and plasma cells, most of the lymph nodes Full of positive cells. From 30 days onwards, the positive cells in the cortex and medulla area are urgently and vice versa, to 50 days, there are only a few scattered positive cells in the lymph nodes, some of the cells become irregular shaped residual plasma cells.