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目的:评价子宫动脉灌注新辅助化疗在Ⅱ期子宫颈癌治疗中的作用。方法:临床观察90例Ⅱ期子宫颈鳞状细胞癌患者,术前采用Seldinger技术子宫动脉插管灌注化疗,化疗后施行子宫广泛切除术及盆腔淋巴结清扫术或根治性放疗。结果:子宫动脉灌注化疗治疗Ⅱ期子宫颈癌有效率为65.56%,其中4例组织学完全缓解(4.44%)。结论:选择性子宫动脉灌注化疗可有效缩小局部肿瘤、改善宫旁情况,提高了Ⅱ期子宫颈癌可手术切除率,近期疗效明显,但长期疗效有待于进一步观察。
Objective: To evaluate the role of uterine artery infusion neoadjuvant chemotherapy in the treatment of stage Ⅱ cervical cancer. Methods: Ninety patients with cervical squamous cell carcinoma of stage Ⅱ were observed clinically. Seldinger technique was used to preoperatively uterine arterial cannulation. Chemotherapy was followed by extensive hysterectomy and pelvic lymph node dissection or radical radiotherapy. Results: The effective rate of uterine arterial infusion chemotherapy for stage Ⅱ cervical cancer was 65.56%, of which 4 cases were completely relieved histologically (4.44%). Conclusion: Selective uterine arterial infusion chemotherapy can effectively reduce the local tumor, improve the situation of the uterus and improve the resectable rate of cervical cancer in stage Ⅱ, with obvious short-term curative effect, but the long-term curative effect needs to be further observed.