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目的 探讨转移相关基因CD4 4V6与正常胃粘膜、胃异常增生组织及胃癌组织中某些生物学行为的关系。方法 采用免疫组化SP法 ,检测正常胃粘膜 30例、胃异常增生粘膜组织 30例、胃癌原发灶 84例CD4 4V6的表达。结果 CD4 4V6在正常胃粘膜呈阴性表达 ;胃异常增生粘膜组织、胃癌组织呈阳性表达 ,其中异常增生 2 0 0 0 % ,胃癌中肠型胃癌 (71 4 3% )明显高于弥漫型胃癌 (37 14 % ) (P <0 0 5 ) ;淋巴结转移组(87 87% )明显高于无淋巴结转移 (38 77% ) (P <0 0 5 ) ;CD4 4V6阳性率与肿瘤大小无关 (P >0 0 5 ) ;不同胃癌病理分型中淋巴结CD4 4V6阳性率差异无显著意义 (P >0 0 5 )。结论 CD4 4V6阳性表达同胃癌生物学行为密切相关 ,是预测侵袭与转移有价值的指标。
Objective To investigate the relationship between the metastasis-associated gene CD4 4V6 and some biological behaviors in normal gastric mucosa, gastric dysplasia and gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of CD4 4V6 in 30 cases of normal gastric mucosa, 30 cases of dysplasia mucosa, and 84 cases of primary gastric cancer. Results The expression of CD4 4V6 was negative in normal gastric mucosa. The mucosal tissue and gastric cancer tissues were positively expressed in dysplasia of the stomach. Among them, 20% had abnormal hyperplasia and 74.3% of gastric carcinoma was significantly higher than diffuse gastric cancer (71 4 3%). 37 (14%) (P <0 05) lymph node metastasis (87, 87%) was significantly higher than that without lymph node metastasis (38, 77%) (P <0 05); CD4 4V6 positive rate was not associated with tumor size (P > 0 0 5 ) ; There was no significant difference in the positive rate of CD4 4V6 lymph node in different gastric cancer pathological types (P > 0 05). Conclusion The positive expression of CD4 4V6 is closely related to the biological behavior of gastric cancer and is a valuable indicator for predicting invasion and metastasis.