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目的：探讨反式－4－氨甲基－环己烷甲酸与人类皮肤色泽改变相关性的规律性。方法：2010年9月～2013年6月，对18例病例取人活体正常皮肤（如下睑松弛术中计划切除皮肤）进行反式－4－氨甲基－环己烷甲酸局部注射，分组不同药物浓度、剂量（补充计量），达到预定剂量后[1]，手术取下左侧受反式－4－氨甲基－环己烷甲酸作用的和右侧未受反式－4－氨甲基－环己烷甲酸作用的皮肤标本，立即分组冷冻储藏[2]。待积累一定数量标本后[3]，对其皮肤色泽进行测定。结果：本组共18例患者，反式－4－氨甲基－环己烷甲酸局部注射后会导致局部皮肤色泽变化。结论：目前认为反式-4-氨甲基-环己烷甲酸与人类皮肤色泽改变存在相关性，不仅为相关反式-4-氨甲基-环己烷甲酸改变皮肤色泽提供临床和实验依据，更可以指导日常生活中对相关药物的正确选择。“,” Objective :Exploring TRANS-methyl-cyclohexane carboxylic acid and the change regularity of the relationship between human skin color. Methods :September 2010 -2013 years June,, takes the person living specimen normal skin (in the fol owing palpebralis relaxation technique to plan to excise skin) to 18 cases of cases to carry on transform - 4- ammonia methyl - naphthenic acid injects partial y, groups the different drug concentration and dosage (supplement measurement), after being the scheduled dosage, left the surgery takes down by transform - 4- ammonia methyl - naphthenic acid function and right not by transform - 4- ammonia methyl - the skin specimen of naphthenic acid function, groups to freeze the preserve immediately. After accumulating the certain amount specimen, determines its skin color. Results :This group 18 cases of patients, transform - 4- ammonia methyl - after naphthenic acid partial injection, wil cause the partial skin color change.Conclusion :At present thinks transform - 4- ammonia methyl -naphthenic acid and human skin color change has the relevance, is not only related transform - 4- ammonia methyl - naphthenic acid change skin color provides clinical and experiment basis, can in the director daily life to the correct choice of related medicine.