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目的:通过查阅相关资料和文献,了解由药物多潘立酮引发的心血管系统不良反应,对相关文献进行整理并分析由药物多潘立酮所致的心血管系统不良反应的临床特点及原因,为临床上合理使用药物多潘立酮提供参考和依据。方法:收集国内外有关于药物多潘立酮所引起的心血管系统不良反应的文献,文献通过检索中国知网全文数据库、万方数据库、维普数据库、加拿大和英国不良反应自愿报告数据库等等,获得关于药物多潘立酮引发的心血管系统不良反应的文献资料。对相关文献资料进行整理和分析,了解发生不良反应的作用机制及对患者所带来的影响。结果:从文献中了解到药物多潘立酮可能发生的不良反应有心脏的骤停,室性早搏,室颤,房颤,尖端扭转,心律失常,心肌梗死及心动过速等,引发这些不良反应的相关因素有:药物所使用的对象、用药剂量的不合理、患者的患病史及与其他药物合并用药等。结论:对于药物多潘立酮的使用应严格按医师或说明书服用,患者使用药物后出现不良反应需立即停药并及时处理,用药需慎重。
OBJECTIVE: To understand the cardiovascular system adverse reactions induced by domperidone and to find out the clinical characteristics and causes of adverse cardiovascular reactions caused by domperidone, and to analyze the related literatures. Drug Domperidone provide a reference and basis. Methods: We collected literatures about adverse reactions of cardiovascular system caused by domperidone in our country and abroad. The literatures retrieved the data of Chinese medicine net full-text database, Wanfang database, VIP database, Canadian and British voluntary reports database of adverse reactions and so on, Literature related to domperidone-induced adverse cardiovascular events. Organize and analyze the relevant literature to understand the mechanism of adverse reactions and the impact on patients. Results: It is known from the literature that possible adverse reactions of the drug domperidone include cardiac arrest, premature ventricular contractions, ventricular fibrillation, atrial fibrillation, torsades de pointes, arrhythmia, myocardial infarction and tachycardia, which are associated with these adverse reactions Factors include: the drug used by the object, the dosage is unreasonable, the patient’s medical history and other drugs combined with medication. Conclusion: The use of domperidone should be taken strictly according to the physician or instruction manual. Patients should be discontinued immediately and treated promptly after using the drug. The medication should be cautious.