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Two series of territrem B analogues (6, 11) were designed and synthesized from jujubogenin 2. Compound 11c inhibited AChE with the ratio of 70% at 10-4 mol/L. Compounds5a, 5b, 6a and 11b showed moderate cytotoxicity on cultured KB cells at 10-6 mol/L.Compounds 5c and 6b alleviated injury arising from oxygen-glucose deprivation (OGD).