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目的探讨右旋糖酐铁口服液治疗儿童轻中度缺铁性贫血的临床意义。方法 82例儿童轻中度缺血性贫血患儿,按照随机数字表法分为观察组和对照组,各41例。观察组采用右旋糖酐铁口服液治疗,对照组则采用葡萄糖酸亚铁糖浆治疗。观察两组治疗效果。结果两组治疗前各指标比较差异无统计学意义(P>0.05),治疗后观察组血红蛋白、红细胞计数、红细胞平均血红蛋白浓度及血清铁蛋白均高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率97.6%高于对照组的85.4%,差异有统计学意义(P<0.05)。观察组发生腹泻1例,不良反应发生率为2.4%;对照组发生恶心、呕吐7例,腹泻3例,不良反应发生率为24.4%,其中2例不能耐受而分别于治疗后7、10 d改为右旋糖酐铁口服液治疗;观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论右旋糖酐铁口服液治疗儿童轻中度缺铁性贫血疗效确切,安全性高,值得临床推广。
Objective To investigate the clinical significance of dextran oral liquid in the treatment of mild and moderate iron deficiency anemia in children. Methods 82 cases of children with mild to moderate ischemic anemia were divided into observation group and control group according to random number table method, 41 cases in each group. The observation group was treated with dextran oral liquid, while the control group was treated with glucose ferrous syrup. Observation of two groups treatment effect. Results There was no significant difference in each index between the two groups before treatment (P> 0.05). The hemoglobin, erythrocyte count, mean erythrocyte hemoglobin concentration and serum ferritin in the observation group after treatment were all significantly higher than those in the control group (P < 0.05). The observation group, the total effective rate was 97.6% higher than the control group, 85.4%, the difference was statistically significant (P <0.05). One case of diarrhea occurred in the observation group and the incidence of adverse reactions was 2.4%. In the control group, nausea and vomiting occurred in 7 cases and diarrhea in 3 cases. The incidence of adverse reactions was 24.4%, of which 2 cases were unable to tolerate, d to dextran oral liquid treatment; observation group adverse reactions were lower than the control group, the difference was statistically significant (P <0.05). Conclusion Dextran oral liquid treatment of children with mild to moderate iron deficiency anemia curative effect is safe, it is worthy of clinical promotion.