小肠缺血-再灌注不仅导致局部损伤,而且引起远处脏器损伤。可能有多种机制:中性粒细胞活化、磷脂酶A_2释放以及各种其它介质的释放等,导致一系列病理生理改变。其早期显著的病理生理改变是持续的血流动力学异常,导致组织低灌注和随后的多脏器衰竭,甚至危及生命。肿瘤坏死因子(TNF)-α抗体可阻止多脏器衰竭,尤其是肺和肝。本研究旨在评价 Intestinal ischemia-reperfusion leads not only to local damage but also to distant organ damage. A variety of mechanisms are possible: neutrophil activation, phospholipase A 2 release and release of various other mediators, leading to a series of pathophysiological changes. Its early significant pathophysiological changes are persistent hemodynamic abnormalities, leading to hypoperfusion and subsequent multiple organ failure, even life-threatening. Tumor necrosis factor (TNF) -alpha antibodies can prevent multiple organ failure, especially lung and liver. This study aims to evaluate