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选择未经维生素D补充的1～8月龄母乳喂养婴儿55名,随机分为两组,实验组鼓励多晒太阳;另一组为自然对照。观察两个月,婴儿膳食仅为母乳、果汁和糖水。户外活动时仅暴露面部和前臂。实验开始时,55名婴儿血中25羟胆钙化醇(25-OH-D))浓度低于参考标准低限11ng/ml者约占20％,X线片可诊断为佝偻病者约占18％。两种诊断指标的符合率为68.6％。乳母血中25-OH-D浓度平均为21.9ng/ml,与其婴儿血中25-OH-D浓度相关系数为0.464,相关非常显著。观察期间,婴儿平均每天户外活动时间实验组为116分钟,对照组为63分钟。实验组实验前后血中25-OH-D浓度为29.7±13.3和38.1±20.0ng/ml,差异显著(P<0.01):对照组为20.6±15.5和19.1±13.4ng/ml前后无差异。两组婴儿血中25-OH-D浓度与各自户外活动计分数呈显著相关(r=0.668和0.631)。后者又与日光紫外线照到体表时间(秒)呈相关(r=0.580)。提示婴儿每周户外活动的计分数在800～1000时,可以维持血中25-OH-D浓度在正常范围。
Fifty-five breast-fed infants from 1 to 8 months without vitamin D supplementation were randomly divided into two groups. The experimental group encouraged more sun exposure; the other group was natural control. During the two months of observation, the infant’s diet consisted exclusively of breast milk, juice and syrup. Outdoor activities expose only the face and forearm. At the start of the experiment, 25 infants who had 25-hydroxy-cholecalciferol (25-OH-D) in their infants at a level below the reference limit of 11 ng / ml accounted for about 20% of the total, and X-rays were diagnosed as about 18% . The coincidence rate of the two diagnostic indicators was 68.6%. The average 25-OH-D concentration in maternal blood was 21.9 ng / ml, which was significantly correlated with the 25-OH-D concentration in infants’ blood with a correlation coefficient of 0.464. During the observation period, the average outdoor daily activity of infants was 116 minutes in the experimental group and 63 minutes in the control group. The concentrations of 25-OH-D in the experimental group before and after the experiment were 29.7 ± 13.3 and 38.1 ± 20.0ng / ml, respectively, with significant difference (P <0.01). There was no difference between the control group before and after 20.6 ± 15.5 and 19.1 ± 13.4ng / ml. The concentrations of 25-OH-D in the two groups of infants were significantly correlated with the scores of their respective outdoor activities (r = 0.668 and 0.631). The latter is related to sunlight (UVS) to the body surface in seconds (r = 0.580). Prompt baby weekly outdoor activities scoring 800 ~ 1000, you can maintain blood 25-OH-D concentration in the normal range.