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目的:探讨不明原因不孕与微量元素的关系,微量元素对女性不孕的影响,为不明原因不孕的诊断提供新的监测手段和治疗途径。方法:应用原子吸收分光度法测定38例不明原因不孕和35例已育健康妇女血清中锌(Zn)、铜(Cu)、铁(Fe)、钙(Ca)、镁(Mg)、铅(Pb)含量,应用化学发光免疫法测定血清FSH、LH、E2、PRL、P、T水平,结合B超、BBT监测排卵。结果:不孕组血清微量元素Zn、Fe、Ca含量低于对照组,差异均有统计学意义(P<0.05)。不孕组血清Cu含量则高于对照组,差异具有统计学意义(P<0.05)。不孕组和对照组血清Mg、Pb含量差异无统计学意义(P>0.05)。无排卵者血清Zn含量低于排卵者,差异具有统计学意义(P<0.05)。无排卵者血清Cu含量高于排卵者,差异具有统计学意义(P<0.05)。结论:不明原因不孕的妇女可能与体内微量元素如Zn、Cu、Fe、Ca等比例失调,代谢紊乱有关,而导致内分泌腺的结构异常和功能紊乱,导致排卵障碍,影响女性的生殖过程。
Objective: To explore the relationship between unexplained infertility and trace elements, the effect of trace elements on female infertility and to provide new means of monitoring and treatment for the diagnosis of unexplained infertility. Methods: Serum levels of Zn, Cu, Fe, Ca, Mg, Pb and Pb in 38 unexplained infertile women and 35 healthy women were measured by atomic absorption spectrophotometry. (Pb) levels were determined. Serum levels of FSH, LH, E2, PRL, P and T were measured by chemiluminescence immunoassay. Combined with B ultrasound and BBT, ovulation was monitored. Results: The contents of trace elements Zn, Fe and Ca in infertility group were lower than those in control group (P <0.05). The content of serum Cu in infertility group was higher than that in control group, the difference was statistically significant (P <0.05). There was no significant difference in serum Mg and Pb levels between infertility group and control group (P> 0.05). The serum Zn level of anovulation was lower than that of ovulation, the difference was statistically significant (P <0.05). The serum Cu content of anovulation was higher than that of ovulation, the difference was statistically significant (P <0.05). CONCLUSIONS: Women with unexplained infertility may be related to imbalances and metabolic disorders such as Zn, Cu, Fe, Ca and other metabolic disorders, leading to structural abnormalities and dysfunction of endocrine glands leading to ovulation disorders and affecting the female reproductive process.