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目的 :研究雌激素受体 (ER)、孕激素受体 (PR)在 40例胆囊癌中表达和AgNOR在胆囊癌中含量及形态变化的关系。方法 :用免疫组化ABC法和AgNOR技术对胆囊正常上皮和癌上皮进行实验测定。结果 :胆囊正常上皮ER、PR为阴性 ,癌上皮ER2 6例 (6 5 %)阳性 ,PR2 0例 (5 0 %)阳性 ,核仁组成区相关蛋白 (AgNOR)表示颗粒类型 ,正常上皮为单一型 ,癌上皮主要表现为弥散型 ,其次为混合型。结论 :胆囊癌的发生发展对女性激素有一定的依赖性 ,AgNOR计数及形态分类对胆囊癌的生物学行为、预后、病理诊断及治疗均有一定的参考价值。
Objective: To study the relationship between the expression of estrogen receptor (ER) and progesterone receptor (PR) in 40 gallbladder carcinomas and the content and morphous of AgNOR in gallbladder carcinomas. Methods: Immunohistochemical ABC method and AgNOR technique were used to determine the normal gallbladder epithelium and carcinoma epithelium. Results: The ER and PR of the normal gallbladder were negative. The positive expression of ER2 was positive in 6 cases (65%) and PRO was found in 50 cases (50%). The positive expression of AgNOR in granulocyte was normal Type, the main manifestations of cancer epithelial diffuse type, followed by mixed type. Conclusion: The occurrence and development of gallbladder carcinoma have some dependence on female hormones. AgNOR count and morphological classification have certain reference value for the biological behavior, prognosis, pathological diagnosis and treatment of gallbladder cancer.