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目的探讨IL-8、IL-10、TNF-α及转化生长因子-β1(TGF-β1)在癫发作中的作用及临床意义。方法选择新诊断的癫病例16例,并设健康对照组10例,采用ELISA方法进行血清IL-8、IL-10、TNF-α及TGF-β1水平测定。结果癫组血清IL-10、TGF-β1和TNF-α水平较正常对照组差异有统计学意义(Z=2.97～42.96,P均<0.01),癫组血清IL-8水平较正常组儿童增高,但两者之间差别无统计学意义(Z=1.48,P>0.05)。结论癫患儿发作后存在免疫功能的紊乱,下调免疫功能的因子(IL-10和TGF-β)水平显著增高,提示存在明显的免疫抑制现象,可能使机体细胞免疫功能下降;TNF-α显著增高,提示其可能参与了导致脑组织神经功能异常的活动。
Objective To investigate the role of IL-8, IL-10, TNF-α and transforming growth factor-β1 (TGF-β1) in epileptic seizures and their clinical significance. Methods Sixteen newly diagnosed cases of epilepsy were selected and 10 healthy volunteers were enrolled in this study. Serum levels of IL-8, IL-10, TNF-α and TGF-β1 were measured by ELISA. Results The levels of serum IL-10, TGF-β1 and TNF-α in epilepsy group were significantly lower than those in normal control group (Z = 2.97 ~ 42.96, P <0.01) Children increased, but the difference between the two was not statistically significant (Z = 1.48, P> 0.05). Conclusions There is a disorder of immune function and the levels of IL-10 and TGF-β in the epileptic children after the onset of seizures are significantly increased, suggesting that there is a significant immunosuppression, which may decrease the cellular immune function. The level of TNF-α Significantly increased, suggesting that they may be involved in the brain tissue caused by abnormal nerve function of the activity.