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用不同剂量吡喹酮(Embay 8440)治疗63例华支睾吸虫病人:35例为3×25毫克/公斤体重一天疗法,28例为40毫克/公斤体重单剂一天疗法。治后约30天和60天进行复查。第一次或第二次复查发现虫卵者,再以相同剂量的吡喹酮复治,复治后约30天和60天再行复查。3×25毫克/公斤体重组治后二月35例病人中30例粪检转阴,余5例在第二次3×25毫克/公斤体重治疗后而痊愈。单剂40毫克/公斤体重治疗组治后60天28例中仅7例治愈,余21例经第二次40毫克/公斤体重治疗后7例治愈,其余14例虫卵减少率均在90%以上。治后血液学、血液生物化学及尿分析检查均未发现与药物有关的异常改变。患者对这种驱虫剂耐受良好,副反应极少,为轻度而短暂的头痛和头晕。两个剂量组之间没有明显差异。研究结果表明吡喹酮可能被选为治疗人体华支睾吸虫病的药物,也可用于大规模的治疗。
Sixty-three patients with Clonorchis sinensis were treated with different doses of praziquantel (Embay 8440): 35 for 3 x 25 mg / kg body weight daily and 28 for 40 mg / kg body weight single-day regimens. About 30 days after treatment and 60 days for review. The first or second review found that the eggs, and then the same dose of praziquantel retreatment, retreatment about 30 days and 60 days after the re-examination. Thirty cases of 35 cases of patients with 3 × 25 mg / kg body weight regained in February were stool negative and the remaining 5 cases recovered after the second 3 × 25 mg / kg body weight treatment. A single dose of 40 mg / kg body weight treatment group 60 days after treatment, only 7 cases were cured in 28 cases, the remaining 21 cases by the second 40 mg / kg body weight after 7 cases of cure, the remaining 14 cases of egg reduction rates were 90% the above. Post-hematology, blood biochemistry and urinalysis examination found no abnormal changes associated with the drug. The patient is well tolerated with this repellent with minimal side effects, with mild and transient headaches and dizziness. There was no significant difference between the two dose groups. The results show that praziquantel may be selected as a treatment for human Clonorchiasis medicine, but also for large-scale treatment.