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目的:优选最佳的分离纯化红参中人参总皂苷的工艺条件。方法:以人参总皂苷的量为指标,比较不同型号树脂和不同工艺条件对人参总皂苷的分离纯化能力。结果:确定HPD-400大孔树脂为人参总皂苷的纯化材料,其最佳工艺条件是药液质量浓度1.7 g·L-1,药液pH 4.68,吸附速度7.5 BV.h-1,用4 BV80%乙醇以7.5 BV.h-1的速度洗脱人参总皂苷。结论:本工艺条件可以用于含有人参总皂苷的中药制剂的制备提供依据。
Objective: To optimize the conditions for the separation and purification of ginseng total saponin. Methods: The total ginsenoside amount as an indicator to compare different types of resin and different process conditions on the ginsenosides isolation and purification capabilities. Results: The HPD-400 macroporous resin was identified as a purified material of total ginsenoside. The optimum conditions were as follows: liquid mass concentration 1.7 g · L -1, liquid pH 4.68, adsorption rate 7.5 BV · h -1, BV80% ethanol eluted ginseng total saponin at a rate of 7.5 BV.h-1. Conclusion: The process conditions can be used to provide the basis for the preparation of traditional Chinese medicine preparations containing ginsenosides.