论文部分内容阅读
[目的]探讨rasP21蛋白在焦炉工血清中随接触时间的表达变化,以期用于焦炉工肺癌的早期筛选。[方法]2004~2008年对某煤气化公司焦化厂25名焦炉工连续进行血清rasP21蛋白检测,并与16名同集团公司的不接触职业性致癌物的库房管理人进行比较。[结果]2004~2008年血清P21水平,16名对照者有逐年增高的趋势(P<0.05),25名焦炉工均保持在较高水平(P>0.05);各年接触组均高于对照组(P<0.01或<0.05)。广义估计方程分析结果,分组、观察时间、起始年龄、饮茶(保护因素)与血清P21蛋白水平有统计学意义(P<0.01)。[结论]焦炉工血清P21高于对照组,随着时间的延长2组P21水平均越高,喝茶者血清P21水平较低。
[Objective] To investigate the change of rasP21 protein in contact with coke oven workers serum in the hope of being used in early screening of lung cancer in coke oven workers. [Method] Twenty-five coke oven workers in a coal-fired company's coke plant were tested for serum rasP21 protein continuously from 2004 to 2008 and compared with 16 warehouse managers who did not contact with occupational carcinogens in the same group. [Results] The levels of serum P21 in 2004-2008 increased year by year in 16 control subjects (P <0.05), and 25 workers in coke oven furnace maintained a relatively high level (P> 0.05). The exposure groups in each year were all higher than those in control group Control group (P <0.01 or <0.05). The results of generalized estimating equation, grouping, observation time, starting age, drinking tea (protective factor) and serum P21 protein level were statistically significant (P <0.01). [Conclusion] Coke oven workers serum P21 higher than the control group, with the extension of time P21 levels were higher in both groups, tea drinker serum P21 lower.