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目的:探讨循环纤维细胞、血清淀粉样蛋白P(SAP)在哮喘发病中的作用及其相关性。方法:收集健康志愿者和哮喘患者外周血,分别用流式细胞仪检测单个核细胞中循环纤维细胞百分比,ELISA法检测血清中SAP浓度,并对哮喘患者上述两个指标进行相关分析。结果:哮喘患者体内循环纤维细胞(CD45+ColⅠ+细胞)的百分比显著高于健康志愿者,而SAP浓度显著低于健康志愿者,在哮喘患者,两者呈负相关(r=-0.566,P<0.05)。结论:哮喘患者体内循环纤维细胞比例上调,而SAP浓度下调,且两者之间呈负相关,提示SAP可能作为哮喘气道重塑的一个生物学标志。
Objective: To investigate the role of circulating fibrocytes and serum amyloid P (SAP) in the pathogenesis of asthma and their correlation. Methods: Peripheral blood was collected from healthy volunteers and asthmatic patients. The percentage of circulating fibroblasts in mononuclear cells was detected by flow cytometry. The concentration of SAP in serum was detected by ELISA. The correlation between the above two indexes was analyzed. Results: The percentage of CD45 + ColⅠ + cells in asthmatic patients was significantly higher than that in healthy volunteers, but the SAP concentration was significantly lower in healthy volunteers than in healthy volunteers (r = -0.566, P <0.05). CONCLUSIONS: The proportion of circulating fibroblasts in asthmatic patients is up-regulated while the concentration of SAP is down-regulated, with a negative correlation between the two. This suggests that SAP may serve as a biomarker of airway remodeling in asthma.