为探讨糖尿病外周神经和血浆中一氧化氮 (NO)的变化及渴痹康对其的影响。用 2 %STZ溶液诱导糖尿病大鼠后 ,随机分为 2组 ,即渴痹康防治组和糖尿病对照组 ,另有 1组作正常对照。经 2 .5月防治 ,糖尿病对照组大鼠坐骨神经中NO低于正常组和渴痹康组 (分别P <0 .0 5,P <0 .0 1 ) ;糖尿病对照组大鼠血浆中NO高于正常组和渴痹康组 (分别P <0 .0 5,P <0 .0 1 ) ;渴痹康组与正常组组间比较均无显著性差异。研究显示中药渴痹康对STZ诱导糖尿病大鼠的NO改变有一定的调节作用。 To investigate the changes of nitric oxide (NO) in peripheral nerves and plasma of diabetic patients and the effects of thirsty on them. Diabetic rats were induced with 2% STZ solution and randomly divided into two groups, ie, the Thirty-seven Kang group and the diabetes control group, and another group was used as the normal control. After prevention and treatment of 2.5 months, NO in the sciatic nerve of the diabetic control group was lower than that in the normal group and the Xikukang group (P < 0.05, P <0.01, respectively); There was no significant difference between the normal group and the thirst group (P<0.05, P<0.01). Studies have shown that Chinese herbal medicine Tiegan Kang has a certain regulatory effect on NO changes in STZ-induced diabetic rats.