本文利用Ｈｅｌｉｃｏｂａｃｔｅｒｆｅｌｉｓ感染的小鼠模型进行人类预防幽门螺杆菌感染的疫苗研究。１２０只ＳＰＦ小鼠灌服由Ｈ．ｆｅｌｉｓ超声粉碎抗原及微量霍乱毒素组成的疫苗共５次，同数量的小鼠灌服生理盐水作对照。免疫完成后１、３、６、９、１２、１８个月分组灌服Ｈ．ｆｅｌｉｓ活菌以检验免疫效果。结果显示：实验组动物感染率除３个月为１２％外，余时间均为０，对照组感染率均为１００％。提示通过口服途径可使动物获得高效而持久的抵御螺杆菌的免疫力。 In this paper, Helicobacterfelis infected mouse model for human prevention of Helicobacter pylori infection vaccine research. 120 SPF mice fed by H. felis ultrasonic smash antigen and trace amount of cholera toxin consisting of a total of 5 vaccines, the same number of mice fed with saline as a control. H groups were given 1, 3, 6, 9, 12 and 18 months after the immunization was completed. Live felis to test for immune effects. The results showed that in the experimental group, except for 3 months, the infection rate of animals was 0 and the remaining time was 0, while the infection rate of the control group was 100%. Tip through the oral route allows animals to obtain efficient and durable against Helicobacter immunity.