目的:探讨已婚妇女子宫颈人乳头状瘤病毒(HPV)感染的相关危险因素。方法:根据妇科常规检查及病理学检查结果,将3 600例已婚妇女分为有宫颈HPV感染380例和未有宫颈HPV感染3 220例,应用非条件Logistic回归分析分别进行单因素和多因素分析。结果:单因素分析结果表明,两组间年龄≥30岁、初次性生活年龄<20岁、孕次≥2次、性伴侣≥2个、受教育≥12年、使用避孕套的差异有统计学意义(P<0.05),其中年龄≥30岁、初次性生活年龄<20岁、孕次≥2次、性伴侣≥2个、受教育≥12年与已婚妇女宫颈HPV感染的发生呈正相关(P<0.05);使用避孕套与已婚妇女宫颈HPV感染的发生呈负相关(P<0.05)。进一步行多因素分析结果表明,受教育≥12年、性伴侣≥2个是已婚妇女宫颈HPV感染发生的独立危险因素(P<0.05),使用避孕套是已婚妇女宫颈HPV感染发生的保护因素。结论:文化程度越高及性伴侣越多的已婚妇女,可以明显增加宫颈HPV感染的风险,而使用避孕套可以有效降低宫颈HPV感染的发生,因此对高危人群需进行必要的健康教育,并定期进行宫颈疾病筛查。 Objective: To investigate the risk factors associated with cervical papillomavirus (HPV) infection in married women. Methods: According to the results of gynecological routine examination and pathological examination, 3 600 married women were divided into 380 cases with cervical HPV infection and 3 220 cases without cervical HPV infection. Unconditional Logistic regression analysis was used to analyze single factor and multifactorial factors analysis. Results: The results of univariate analysis showed that the difference between the two groups was statistically significant (P> 0.05) .Conclusion (P <0.05), of which age ≥30 years old, the age of first sexual life <20 years, the second or second pregnancy, sexual partners ≥2 years, education ≥12 years and married women with cervical HPV infection was positively correlated P <0.05). There was a negative correlation between the use of condoms and cervical HPV infection in married women (P <0.05). Further analysis of multivariate analysis showed that education ≥ 12 years and sexual partners ≥2 were independent risk factors for cervical HPV infection in married women (P <0.05). The use of condoms was the protection of cervical HPV infection in married women factor. Conclusion: Married women with higher education level and more sexual partners can significantly increase the risk of cervical HPV infection. However, using condoms can effectively reduce the incidence of HPV in the cervix, so necessary health education is needed for high-risk groups and Cervical disease screening regularly.