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α-巯基丙酰甘氨酸(α-MPG)广泛应用于治疗慢性肝病。无论在体内或体外,α-MPG都可解除铅对家兔δ-ALA-D的抑制。对27名职业性铅接触工人作了临床效果的评价。他们的年龄为30～63岁(平均48岁),接触铅年限1～26年(平均15.6年);全部有铅吸收增加和卟啉代谢异常的体征。工人们在10天内接受了30gα-MPG注射(溶于250ml0.9%盐水);注射前后测定了δ-ALA-D活性、红细胞原卟啉、血尿中δ-ALA和尿中粪卟啉。结果:治疗后ALA-D活性增高,尿δ-
Alpha-mercaptopropionylglycine (α-MPG) is widely used in the treatment of chronic liver disease. Both in vivo and in vitro, α-MPG can relieve the inhibition of lead δ-ALA-D in rabbits. The clinical effect of 27 occupational lead exposed workers was evaluated. Their age ranged from 30 to 63 years (mean, 48 years). Lead exposures ranged from 1 to 26 years (mean, 15.6 years), with all signs of increased lead absorption and abnormal porphyrin metabolism. Workers received 30 g of α-MPG in 10 days (dissolved in 250 ml of 0.9% saline); δ-ALA-D activity, erythrocyte protoporphyrin, δ-ALA in urine and urinary fecal porphyrin were measured before and after injection. Results: ALA-D activity increased after treatment, urinary δ-