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目的:探讨单独HIV感染及HIV合并HCV感染患者血清肝功能指标,外周血T淋巴细胞亚群计数及肝纤维化结果变化。方法:采集2017年1-6月门诊单纯性HIV感染患者(40例),HIV,HCV共感染患者(15例)的标本,用全自动生化分析仪检测肝功能,流式细胞仪检测CD3+,CD4+,CD8+T淋巴细胞。全自动免疫分析仪检测肝纤维化指标。并采用SPSS20软件进行统计学分析。结果:HIV/HCV共感染组ALT,ASTGGT,CG水平高于HIV单独感染者(P<0.05)。而CD4+计数及CD4+/CD8+低于HIV单独感染者(P<0.05)。HIV/HCV共感染组HA高于HIV单独感染组(P<0.05)而层粘连蛋白(LN),IV型胶原(IVC),Ⅲ型前胶原(PCⅢ)虽均增高但P>0.05,差异无显著性。结论:HCV合并HIV感染加重HIV病程,加重肝脏损伤。
Objective: To investigate the changes of serum liver function indexes, count of peripheral blood T lymphocyte subsets and hepatic fibrosis in HIV infection and HIV-infected patients with HCV infection. Methods: Samples of HIV-infected patients and HIV-infected patients (15 cases) from January to June in 2017 were enrolled in this study. Liver function was detected by automatic biochemical analyzer. CD3 + CD4 +, CD8 + T lymphocytes. Automatic immune analyzer to detect liver fibrosis indicators. SPSS20 software was used for statistical analysis. Results: The levels of ALT, ASTGGT and CG in HIV / HCV coinfection group were higher than those in HIV alone group (P <0.05). While CD4 + counts and CD4 + / CD8 + were lower than those of HIV alone (P <0.05). The HA in HIV / HCV co-infected group was higher than that in HIV infected group (P <0.05), while LN, IVC and PCⅢ were both increased but P> 0.05, with no difference Significance. CONCLUSIONS: HIV combined with HIV aggravates HIV progression and aggravates liver damage.