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目的:研究飞行人员血压水平对血管性假血友病因子(vWF)、6-酮-前列腺素F1浕(6-K-PGF1浕)水平和血小板衍生生长因子(PDGF)活性的影响。方法:采用调查问卷和体检的方式了解空军某部飞行人员259例的一般情况和临床资料,同时采用酶标法测定vWF、6-K-PGF1浕水平和PDGF活性。结果:(1)理想血压107例,正常血压78例,1级高血压35例,2级高血压27例,3级高血压12例;(2)1、2、3级高血压组vWF、6-K-PGF1浕水平和PDGF活性与正常血压组及理想血压组比较,差异显著或非常显著(P<0.05,P<0.01)。结论:随着血压水平的增高,血管内皮损伤程度逐渐加重。
Objective: To study the effect of blood pressure level on vWF, 6-K-PGF1 level and PDGF activity in pilots. Methods: The questionnaire and physical examination were used to understand the general situation and clinical data of 259 air force pilots. Meanwhile, the levels of vWF, 6-K-PGF1 and PDGF were determined by enzyme-linked immunosorbent assay. Results: (1) There were 107 cases of ideal blood pressure, 78 cases of normal blood pressure, 35 cases of grade 1 hypertension, 27 cases of grade 2 hypertension and 12 cases of grade 3 hypertension. (2) vWF, The level of 6-K-PGF1 / PDGF and the activity of PDGF were significantly or very significantly different from those in normotension and ideal blood pressure group (P <0.05, P <0.01). Conclusion: With the increase of blood pressure level, the degree of vascular endothelial injury gradually aggravates.