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近年来国外开展一种口服合成肽检查胰腺外分泌功能的试验(简称BTPABA试验或PFT)。给病人口服合成肽,N-苯甲酰-L-酪氨酰-对氨基苯甲酸在小肠被胰腺分泌的糜蛋白酶分解释放出对氨基苯甲酸(PABA),并经肾脏由尿排出,收集服药后6小时的尿,用Smith改良的Bratton-Marshall法测定尿中PABA的排出量。借此测定胰腺外分泌功能状态。Imondi等报道,胰腺功能不全的动物,尿中PABA排出量明显降低。Gyr和Arvanitaks等首先将此试验应用于临床。近年来多数作者报道,胰腺外分泌功能障碍病人,尿中PABA排出率明显下降。此法测定的结果与促胰酶素/胰泌素试验、Lundh试餐试验等显著相关。本试验突出优点是方法简便,不需特殊设备,不用插管收集胰液,病人易于接受,便于推广,且可多次重复检查胰腺功能的变化。我们在有关方面协助下,首次合成了BTPABA,并取得较满意的结果。
In recent years abroad to carry out a test of oral synthesis of pancreatic exocrine function (abbreviated BTPABA test or PFT). Oral synthetic peptide to patients, N-benzoyl-L-tyrosyl-p-amino benzoic acid in the small intestine by the secretion of chymotrypsin release of p-aminobenzoic acid (PABA), and excreted by the kidneys from the urine, the collection of medication Six hours after urination, the amount of PABA excreted in the urine was measured using Smith’s modified Bratton-Marshall method. To determine pancreatic exocrine function. Imondi et al reported that in animals with pancreatic insufficiency, urinary PABA release was significantly reduced. Gyr and Arvanitaks first applied this test to clinical trials. Most authors reported in recent years, pancreatic exocrine dysfunction in patients with urinary PABA significantly decreased the rate of discharge. The results of this assay were significantly associated with the pancreasein / secretin test, the Lundh test meal test, and the like. This test highlights the advantages of the method is simple, no special equipment, no catheter to collect pancreatic juice, the patient is easy to accept, easy to promote, and can repeatedly check the changes in pancreatic function. With the help of relevant parties, we first synthesized BTPABA and achieved satisfactory results.