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目的比较卡前列素氨丁三醇与米索前列醇防治宫缩乏力性产后出血的效果及不良反应。方法 70例宫缩乏力性产后出血高危因素的产妇根据数字表法随机分为2组,A组(n=35例)采用米索前列醇防治宫缩乏力性产后出血,B组(n=35例)采用卡前列素氨丁三醇防治宫缩乏力性产后出血。比较两组临床疗效、产后出血发生率、产后2 h和24 h出血量、第三产程时间、血红蛋白下降值及不良反应发生率。结果 B组治疗总有效率(94.29%)明显高于A组(77.14%)(P<0.05);B组产后2 h出血量、产后24 h出血量明显少于A组(P<0.05),第三产程时间明显快于A组(P<0.05),产后出血发生率和血红蛋白下降值明显高于A组(P<0.05);两组治疗期间均未出现严重不良反应,A组不良反应发生率(20.0%)与B组(14.29%)比较,差异无统计学意义(P>0.05)。结论卡前列素氨丁三醇防治宫缩乏力性产后出血的效果优于米索前列醇,可明显降低产后出血率。
Objective To compare the efficacy and side effects of carboprost trometamol and misoprostol in the prevention and treatment of uterine inertia postpartum hemorrhage. Methods Seventy patients with atherogenic risk factors for postpartum hemorrhage were randomly divided into two groups according to digital table method. Group A (n = 35) was treated with misoprostol to prevent postpartum uterine bleeding. Group B (n = 35) Cases) with card prostaglandin trometamol prevent uterine inertia postpartum hemorrhage. The clinical efficacy, the incidence of postpartum hemorrhage, the amount of hemorrhage at 2 h and 24 h postpartum, the duration of the third stage of labor, the hemoglobin decrease and the incidence of adverse reactions were compared between the two groups. Results The total effective rate (94.29%) in group B was significantly higher than that in group A (77.14%) (P <0.05). The amount of bleeding at 2 h postpartum was significantly less in group B than in group A (P <0.05) The duration of the third stage of labor was significantly faster than that of group A (P <0.05), and the incidence of postpartum hemorrhage and hemoglobin decreased significantly (P <0.05). No serious adverse reactions occurred in the two groups during treatment, and adverse reactions in group A occurred There was no significant difference in the rate (20.0%) compared with that in group B (14.29%) (P> 0.05). Conclusion The effect of carboprost trometamol in preventing postpartum hemorrhage due to uterine inertia is better than that of misoprostol, which can significantly reduce the rate of postpartum hemorrhage.