莱姆病是一种由伯氏疏螺旋体(Bb)引起的复发性多系统性疾病。在美国这是一种常见的节肢动物感染所致的疾病,若不及时诊治,会发展为心脏炎、关节炎、肾炎等慢性疾病。Bb可以在传病媒介硬蜱属蜱和哺乳动物宿主鼠类等中找到。本文着重于研究Bb在两种不同生存环境中,基因和蛋白质表达的变化。为了分析Bb在哺乳动物宿主中的状况,研究者从B_(31)-MI株中得到含有所有质粒的B31c8克隆,然后用微阵列技术结合大鼠透析膜小室(dialysis mem- Lyme disease is a recurrent, multisystem disease caused by Borrelia burgdorferi (Bb). In the United States this is a common arthropod infection caused by the disease, if not timely diagnosis and treatment, will develop into heart disease, arthritis, nephritis and other chronic diseases. Bb can be found in the vectors Ixodes ticks and mammalian host mice and the like. This article focuses on the changes of Bb gene and protein expression in two different living environments. To analyze the status of Bb in mammalian hosts, the researchers obtained a B31c8 clone containing all the plasmids from the B_ (31) -MI strain and then used microarray technology in conjunction with the dialysis mem-