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抗菌素和氯丙嗪在临床上常常合并应用,有文报导氯丙嗪有加剧实验性感染的作用.本实验室曾发现氯丙嗪在试管内有增强青霉素对耐青霉素金黄色葡萄球菌的抑制作用.为了探讨这个问题,本文以这个菌株制成5％粘液素菌悬液腹腔感染小鼠,在不同时间由背部皮下给青霉素及腹部皮下给氯丙嗪进行治疗,观察合并用药的效果.实验结果说明,当每鼠感染10(~-4)菌液0.5毫升(约2×10~4个活菌)后,给不同量的氯丙嗪,明显地看出5毫克/公斤的氯丙嗪有加剧感染的作用,小鼠4天内生存率为6.7％,而不给氯丙嗪的对照组为53.3％;感染量减低10倍时,给氯丙嗪组为40％,对照组为86.7 ％.
Antibiotics and chlorpromazine are often used in clinical practice, there are reports of chlorpromazine aggravate the experimental infection in the laboratory chlorpromazine has been found in the test tube to enhance penicillin-resistant penicillin-resistant Staphylococcus aureus In order to explore this problem, this paper made 5% muciclovir suspension of this strain intraperitoneally infected mice, at different times by subcutaneous penicillin from the back and abdominal subcutaneous treatment of chlorpromazine to observe the effect of combined drugs.Experimental results This shows that when each mouse infects 0.5 ml (about 2 x 10-4 viable cells) of 10 (-4) bacteria and gives different amounts of chlorpromazine, it is clear that 5 mg / kg of chlorpromazine is Aggravating the role of infection, the survival rate of mice within 4 days was 6.7%, while the control group did not give chlorpromazine was 53.3%; 10 times lower infection, chlorpromazine group 40%, the control group was 86.7%.