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探讨母亲妊娠合并糖尿病及妊高征对高危儿血糖、胰岛素、皮质醇、胰岛素样生长因子1水平（IGF-1）的影响,检测糖尿病组42例,妊高征组144例,健康对照组23例,均于出生24～48小时内采取股静脉血,测定有关内分泌水平。结果显示:（1）糖尿病组胰岛素、皮质醇水平较对照组显著增高,P<0.05;（2）妊高征组皮质醇水平明显高于对照组,P<0.05;（3）糖尿病与妊高征二组比较,IGF-1有显著性差异,P<0.05。结论,妊娠合并糖尿病及妊高征均对围产儿内分泌产生影响,可引起血皮质醇水平明显升高,尤其以前者为甚,可发生高胰岛素血症及血中IGF-1水平升高,胎儿柯兴氏面容、RDS及巨大儿的发生显著增高,影响围产儿的质量,应引起重视。
To investigate the effects of pregnancy complicated with diabetes mellitus and pregnancy-induced hypertension on blood glucose, insulin, cortisol and insulin-like growth factor-1 (IGF-1) levels in high risk infants, 42 cases of diabetes mellitus, 144 cases of PIH, 23 healthy controls Cases, were born within 24 to 48 hours to take femoral venous blood, determination of endocrine levels. The results showed that: (1) The level of insulin and cortisol in diabetic group was significantly higher than that in control group (P <0.05); (2) Cortisol level in PIH group was significantly higher than that in control group (P <0.05); (3) There were significant differences in IGF-1 between the two groups (P <0.05). Conclusions Pregnancy complicated with diabetes and pregnancy induced hypertension have effects on perinatal endocrine, which can cause the blood cortisol level to rise obviously. Especially in the former, hyperinsulinism and elevated blood levels of IGF-1 may occur. ’S face, RDS and huge children occurred significantly increased, affecting the quality of perinatal children, deserves attention.