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冠状动脉粥样硬化性心脏病(冠心病)是美国成年人的首要死亡原因。2型糖尿病患者具有不成比例的冠心病高发病率和病死率。血脂异常、高血压、促血栓形成因子和促炎症因子均能促进肥胖糖尿病患者的动脉粥样硬化的发生发展。然而,造成糖尿病患者的冠心病发生风险大幅度增加的病理生理机制目前还不明确。
Coronary atherosclerotic heart disease (coronary heart disease) is the leading cause of death among American adults. Patients with type 2 diabetes have a disproportionately high incidence and mortality of coronary heart disease. Dyslipidemia, hypertension, thrombosis factors and pro-inflammatory factors can promote the development of atherosclerosis in obese diabetic patients. However, the pathophysiological mechanism that causes a substantial increase in the risk of coronary heart disease in diabetic patients is not yet clear.