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目的观察血管内皮生长因子-C(VEGF-C)及其受体VEGFR-3与神经细胞黏附分子-接触蛋白-1(contactin-1,CNTN-1)在胃癌组织中的表达情况,并分析其与胃癌淋巴结转移和其临床病理参数间的关系。方法 56例胃癌患者按淋巴结转移情况分成:实验组(淋巴结转移阳性患者34例)和对照组(淋巴结转移阴性患者22例)。对所有肿瘤组织标本行免疫组化染色检测VEGF-C、VEGFR-3及CNTN-1的表达,分析三者之间的关系及其与临床病理特征之间的关系。结果实验组:VEGF-C、VEGFR-3及CNTN-1的阳性表达率分别为67.64%、82.35%及76.47%。对照组:VEGF-C、VEGFR-3及CNTN-1的阳性表达率分别为:40.91%、50.00%及45.45%。CNTN-1的表达与VEGF-C(P<0.05)及VEGFR-3表达(P<0.05)存在明显相关性。三者的表达与TNM分期和淋巴结转移均有关(均P<0.05)。结论 VEGF-C、VEGFR-3和CNTN-1三者均在胃癌组织中高表达。三者的表达情况与肿瘤的淋巴结转移和TNM分期关系密切。而且认为VEGF-C促进胃癌的淋巴管生成和淋巴结转移有可能是通过CNTN-1通路介导的。
Objective To observe the expression of vascular endothelial growth factor-C (VEGF-C) and its receptor VEGFR-3 and neural cell adhesion molecule-1 (CNTN-1) And lymph node metastasis of gastric cancer and its clinicopathological parameters. Methods Fifty-six patients with gastric cancer were divided into two groups based on lymph node metastasis: experimental group (34 cases with positive lymph node metastasis) and control group (22 cases with negative lymph node metastasis). The expressions of VEGF-C, VEGFR-3 and CNTN-1 were detected by immunohistochemical staining in all tumor samples. The relationship between them and the clinicopathological features were analyzed. Results The positive rates of VEGF-C, VEGFR-3 and CNTN-1 in experimental group were 67.64%, 82.35% and 76.47% respectively. The positive rates of VEGF-C, VEGFR-3 and CNTN-1 in control group were 40.91%, 50.00% and 45.45%, respectively. There was a significant correlation between the expression of CNTN-1 and VEGF-C (P <0.05) and VEGFR-3 (P <0.05). The expression of the three were related to TNM staging and lymph node metastasis (all P <0.05). Conclusion The expressions of VEGF-C, VEGFR-3 and CNTN-1 are all highly expressed in gastric cancer. Three of the expression of the tumor and lymph node metastasis and TNM staging are closely related. Moreover, it is considered that VEGF-C promotes lymphangiogenesis and lymph node metastasis of gastric cancer through the CNTN-1 pathway.